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IPT Cancer Treatment

Insulin potentiation therapy, also known as IPT, is a potentially transformative approach to treating cancer. Insulin potentiation therapy uses the hormone insulin, which the body produces naturally, to make cancer cell membranes more permeable. The goal is to make pharmacological treatments more effective.

Dr. Joseph Shaw Jones, Medical Director at Natural Horizons, is one of 135 physicians in the world trained in this innovative, experimental therapy. 

Common Questions

  • How long will my first appointment be?

    Your first appointment with Dr. Shaw Jones will be three to four hours in length.

  • How do I schedule an initial appointment at Natural Horizons?

    Natural Horizons’ highly trained medical and administrative staff is ready to help you. Simply call us to schedule a convenient time for your initial appointment. Our business hours are:

    Monday – Friday: 8AM until 5PM
    Saturday: 9AM until 12 Noon on most Saturdays

    • Toll Free: (877) 292-1571
    • Fax: (703) 267-6977
    • Email:

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How Does Insulin Potentiation Therapy Work?

Cancer cells need glucose to burn for energy. They are almost totally dependent on glucose as their source of energy, while healthy cells use a combination of sugar and fats for their energy needs. With few exceptions, cells require insulin for glucose to enter the cell. Since cancer cells are totally dependent on glucose for energy, they have 6 - 15 times the number of insulin receptors as normal cells.

In addition to allowing glucose to enter cells, insulin makes the cell membrane more permeable to other substances, including chemotherapy drugs.  Because insulin receptors are so concentrated on cancer cells, administering insulin opens the cancer cell membrane, allowing chemotherapy drugs to target the cancer with relatively little effect on normal cells.

Insulin potentiation therapy allows higher concentrations of chemo drugs to enter the cancer cells. In fact, a Georgetown University Medical School study in the 1990s showed the chemotherapy drug methotrexate had the ability to enter cancer cells at a rate 10,000 times greater when the cells were prepared with insulin.

IPT Works in Combination with Low-Dose Chemotherapy

Insulin has properties that encourage cancer cells to enter a phase of DNA synthesis and cell division. During this phase, the cell reproduction mechanism is vulnerable to chemotherapy drugs. Thus, insulin potentiation therapy allows a greater level of chemo drug to enter the cancer cells at a time when they are most vulnerable.

For some cancer patients, this means a far smaller dose of chemotherapy drugs is needed to kill cancer cells. Low-dose chemotherapy means less toxicity to normal cells and fewer side effects for patients. Our low-dose chemotherapy treatment uses 5 - 10% of the standard dose of most chemotherapy drugs.

While low-dose chemotherapy uses the same chemotherapeutic agents as conventional chemotherapy treatments, this low-dose method in combination with insulin potentiation therapy is not widely recognized among conventional oncologists. As with any complementary medicine, it’s important to tell your entire cancer treatment team about your use of IPT and low-dose chemotherapy.

What Does the Research Say About Low-Dose Chemotherapy for Cancer?

In research published by the National Institutes of Health, researcher Christo Damyanov et al. said:

“…IPTLD method provides a real opportunity for resolving one of the most serious problems of toxicity associated with chemotherapy…”

The report went on to conclude:

“…A certain advantage of the method along with its effectiveness is the significantly improved quality of life of the treated patients.” 

Find Out if IPT and Low-Dose Chemotherapy Are Right for You

IPT and low-dose chemotherapy are not suitable for all forms of cancer. These treatments are part of a comprehensive cancer treatment program at Natural Horizons. To find out if these IPT and low-dose chemo are right for you, call for a free consultation with our cancer care specialist.





Dr. Shaw Jones is a medical doctor with extensive experience in natural forms of medicine and IPT, but he is not an oncologist. While the information on this site represents the opinions of Dr. Jones, based upon his knowledge, experience and training as to safety and effectiveness, these recommendations have not been reviewed by the U.S. Food and Drug Administration. The drugs that are used in this protocol are approved for other uses by FDA, either in the treatment of cancer at larger doses or for the treatment of diabetes, but their uses in this protocol are not FDA approved nor are they at this time recognized by the National Cancer Institute (NCI) or other medical societies involved in oncology. The use of insulin in this treatment is an off-label use, and the chemotherapeutic agents are those customarily used for specific tumors, but their use in low doses is outside recommended protocols. Studies in Mexico have been promising, but this research has not been subjected to sufficient validation in order to gain acceptance beyond a small community of physicians.

The material provided on this site is for educational purposes only and any recommendations are not intended to replace the advice of your physician. You are encouraged to seek advice from a competent medical professional regarding the applicability of any recommendations with regard to your symptoms or condition.

It is important that you do not reduce, change, or discontinue any medication or treatment without consulting your physician first.